Biomarkers

Gastric

  • Helicobacter pylori
  • Pepsinogen I and II
  • Gastrin
  • Chromogranin A
  • Somatostatin

Lipid metabolism

  • Free fatty acids and Phospholipid B
  • Apolipoprotein A-1, B, E and C-III
  • Adiponectin
  • Leptin
  • Ghrelin

Bone

  • Bone-specific alkaline phosphatase
  • Growth hormone
  • Intact parathyroid hormone
  • Total MMP-9
  • Osteocalcin

Platelet function and coagulation

  • 11-Dehydro thromboxane B2 in urine
  • 2, 3-dinor-6-keto prostaglandin F1α
  • Factor X PT
  • Heparin activity (HEP LMW)
  • Plasmin inhibitor
  • Platelet aggregation with a variety of stimulants
  • PFA 100
  • Cone and plate analyser

Renal

  • Cystatin C
  • Retinol-binding protein (RBP 4)
  • Urine Beta NAG
  • Renin and aldosterone
  • Corticosterone

Diabetic

  • Insulin and C-peptide
  • Glucagon

Cardiac

  • Troponin I
  • CK-MB
  • Myoglobin
  • BNP

Reproductive

  • Inhibin B
  • Sex hormone-binding globulin (SHBG)
  • DHEA and DHEA-SO4

Inflammation/immunity

  • Gated auto fluorescence forward scatter (GAFs) assay
  • Platelet activation markers & reticulated platelets
  • Neutrophil CD11b and shape change
  • Neopterin
  • Surfactant protein D (SP-D)
  • Myeloperoxidase (MPO)

Cytokine

  • Inflammatory
  • chemokines
  • interferons
  • interleukins
  • lymphokines
  • tumour necrosis factors

 

Cell level biomarkers

We have multicolour flow cytometry capabilities to detect differential expression of cell surface markers and cytokine secretion profiles. We can validate / characterise / accommodate method transfers to determine the phenotype, receptor occupancy, and/or Ab expression levels of cells and their subtypes.

 

Examples of assays we’ve done:

  • enumeration of lymphocyte subsets
  • neutrophil CD11b and neutrophil shape change
  • platelet activation markers & reticulated platelets
  • stem cell enumeration
  • expression of T cell surface receptor Programmed cell death 1 (PD-1)

 

Cell stimulation

  • PMA and ionomycin
  • KLH
  • LPS
  • … etc

 

…and many more!